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Survival of bundleless hair cells and subsequent bundle replacement in the bullfrog's saccule
Journal of neurobiology, 2002-02, Vol.50 (2), p.81-92
Gale, Jonathan E.
Meyers, Jason R.
Periasamy, Ammasi
Corwin, T.
2002
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Gale, Jonathan E.
Meyers, Jason R.
Periasamy, Ammasi
Corwin, T.
Titel
Survival of bundleless hair cells and subsequent bundle replacement in the bullfrog's saccule
Ist Teil von
Journal of neurobiology, 2002-02, Vol.50 (2), p.81-92
Ort / Verlag
New York: Wiley Periodicals, Inc
Erscheinungsjahr
2002
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Our senses of hearing and balance depend upon hair cells, the sensory receptors of the inner ear. Millions of people suffer from hearing and balance deficits caused by damage to hair cells as a result of exposure to noise, aminoglycoside antibiotics, and antitumor drugs. In some species such damage can be reversed through the production of new cells. This proliferative response is limited in mammals but it has been hypothesized that damaged hair cells might survive and undergo intracellular repair. We examined the fate of bullfrog saccular hair cells after exposure to a low dose of the aminoglycoside antibiotic gentamicin to determine whether hair cells could survive such treatment and subsequently be repaired. In organ cultures of the bullfrog saccule a combination of time‐lapse video microscopy, two‐photon microscopy, electron microscopy, and immunocytochemistry showed that hair cells can lose their hair bundle and survive as bundleless cells for at least 1 week. Time‐lapse and electron microscopy revealed stages in the separation of the bundle from the cell body. Scanning electron microscopy (SEM) of cultures fixed 2, 4, and 7 days after antibiotic treatment showed that numerous new hair bundles were produced between 4 and 7 days of culture. Further examination revealed hair cells with small repaired hair bundles alongside damaged remnants of larger surviving bundles. The results indicate that sensory hair cells can undergo intracellular self‐repair in the absence of mitosis, offering new possibilities for functional hair cell recovery and an explanation for non‐proliferative recovery. © 2002 Wiley Periodicals, Inc. J Neurobiol 50: 81–92, 2002; DOI 10.1002/neu.10002
Sprache
Englisch
Identifikatoren
ISSN: 0022-3034
eISSN: 1097-4695
DOI: 10.1002/neu.10002
Titel-ID: cdi_proquest_miscellaneous_18286138
Format
–
Schlagworte
Animals
,
Anti-Bacterial Agents - toxicity
,
Cell Survival - physiology
,
Cells, Cultured
,
deafness
,
Deafness - chemically induced
,
Deafness - physiopathology
,
Freshwater
,
Gentamicins - toxicity
,
Hair Cells, Vestibular - ultrastructure
,
hearing
,
Microscopy, Electron
,
Microscopy, Electron, Scanning
,
ototoxicity
,
Postural Balance
,
Rana catesbeiana
,
regeneration
,
Regeneration - physiology
,
repair
,
saccule
,
Saccule and Utricle - cytology
,
Saccule and Utricle - physiology
,
vestibular
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