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BibTeX
Population-based validation of the recursive partitioning analysis-based staging system for oropharyngeal cancer
Head & neck, 2016-10, Vol.38 (10), p.1530-1538
Keane, Florence K.
Chen, Yu-Hui
Tishler, Roy B.
Schoenfeld, Jonathan D.
Haddad, Robert I.
Goguen, Laura A.
Catalano, Paul
Neville, Bridget A.
Margalit, Danielle N.
2016
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Keane, Florence K.
Chen, Yu-Hui
Tishler, Roy B.
Schoenfeld, Jonathan D.
Haddad, Robert I.
Goguen, Laura A.
Catalano, Paul
Neville, Bridget A.
Margalit, Danielle N.
Titel
Population-based validation of the recursive partitioning analysis-based staging system for oropharyngeal cancer
Ist Teil von
Head & neck, 2016-10, Vol.38 (10), p.1530-1538
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2016
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Background The American Joint Committee on Cancer (AJCC) staging system does not adequately distinguish prognostic groups in the era of human papillomavirus (HPV)‐related oropharyngeal cancer. The purpose of this study was to validate a recursive partitioning analysis (RPA)‐based stage grouping on a population‐wide level. Methods We identified 8427 patients in Surveillance, Epidemiology, and End Results (SEER) with nonmetastatic oropharyngeal cancer with unknown HPV‐status diagnosed from 2004 to 2008. We estimated the overall survival (OS) and head and neck cancer‐specific mortality by RPA stage and AJCC stage and compared the predictive power of the systems. Results RPA stage was significantly associated with OS and head and neck cancer‐specific mortality (p < .0001) with 5‐year OS of 70% for RPA‐I, 55.6% for RPA‐II, and 44.3% for RPA‐III. AJCC stage failed to divide patients into distinct subgroups. RPA stage had significantly improved predictive ability versus AJCC stage for OS (c‐statistic: 0.60 = RPA vs 0.54 = AJCC) and head and neck cancer‐specific mortality (c‐statistic: 0.62 = RPA vs 0.55 = AJCC). Conclusion The RPA‐based stage grouping divided patients into prognostically distinct cohorts and provided superior prediction of OS and head and neck cancer‐specific mortality compared to AJCC staging. © 2016 Wiley Periodicals, Inc. Head Neck 38: First–1538, 2016
Sprache
Englisch
Identifikatoren
ISSN: 1043-3074
eISSN: 1097-0347
DOI: 10.1002/hed.24470
Titel-ID: cdi_proquest_miscellaneous_1827896247
Format
–
Schlagworte
Aged
,
American Joint Committee on Cancer (AJCC) staging system
,
Female
,
head and neck cancer staging
,
Head and Neck Neoplasms - mortality
,
Head and Neck Neoplasms - pathology
,
Human papillomavirus
,
human papillomavirus (HPV)-related cancer
,
Humans
,
Kaplan-Meier Estimate
,
Male
,
Middle Aged
,
Neoplasm Staging - methods
,
Oropharyngeal Neoplasms - mortality
,
Oropharyngeal Neoplasms - pathology
,
oropharyngeal squamous cell cancer
,
Papillomaviridae
,
Prognosis
,
Proportional Hazards Models
,
recursive partitioning analysis-based staging
,
SEER Program
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