Details

Autor(en) / Beteiligte

• Zhang, Yong-Po
• Ma, Zhong-Ying
• Gao, Chun-Yan
• Qiao, Xin
• Tian, Jin-Lei
• Gu, Wen
• Liu, Xin
• Xu, Jing-Yuan
• Zhao, Jin-Zhong
• Yan, Shi-Ping

Titel

Two dpa-based zinc( ii ) complexes as potential anticancer agents: nuclease activity, cytotoxicity and apoptosis studies

Ist Teil von

• New journal of chemistry, 2016-01, Vol.40 (9), p.7513-7521

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Two new mononuclear zinc( ii ) complexes [Zn L X 2 ] 2 ·CH 3 OH (X = Br for 1 , Cl for 2 ) of a tridentate polypyridyl ligand L ( L = 4-methyl- N , N -bis(pyridin-2-ylmethyl)aniline) have been synthesized and structurally characterized. The interactions of two complexes with CT-DNA, pBR322 plasmid DNA and BSA have been explored respectively by using various physico-chemical techniques. Furthermore, the anticancer activities of the complexes towards three human tumor cells lines (HeLa, MCF-7 and RL952) have been studied. The IC 50 values of 1 (on MCF-7 cells) and 2 (on RL952 cells) are 12.58 μM and 11.71 μM, respectively. The apoptosis-inducing activity of 1 was assessed by Hoechst 33342 staining, Annexin V binding and cell cycle analyses.