Details

Autor(en) / Beteiligte

• Papatheodorou, Achilleas, Ph.D
• Vanderzwalmen, Pierre, Ph.D
• Panagiotidis, Yannis, Ph.D
• Petousis, Stamatios, M.D., Ph.D
• Gullo, Giuseppe, M.D
• Kasapi, Evangelia
• Goudakou, Maria, Ph.D
• Prapas, Nikos, M.D., Ph.D
• Zikopoulos, Kostas, M.D., Ph.D
• Georgiou, Ioannis, Ph.D
• Prapas, Yannis, M.D., Ph.D

Titel

How does closed system vitrification of human oocytes affect the clinical outcome? A prospective, observational, cohort, noninferiority trial in an oocyte donation program

Ist Teil von

• Fertility and sterility, 2016-11, Vol.106 (6), p.1348-1355

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective To evaluate whether is possible to vitrify oocytes in an aseptic (hermetically closed) fashion and maintain clinical results comparable with those of fresh oocytes. Design Prospective, observational, cohort, noninferiority trial. Setting Private in vitro fertilization center. Patient(s) One hundred eighty-four recipients of donated vitrified oocytes. Intervention(s) Closed system vitrification. Main Outcome Measure(s) Pregnancy rate per cycle and clinical pregnancy rate per cycle. Result(s) No statistically significant differences were observed between two groups regarding the pregnancy rate per cycle (63.1% vs. 60.9%) or the clinical pregnancy rate per cycle (55.4% vs. 58.7%). Biochemical pregnancy rate was statistically significantly higher in the fresh group (7.6% vs. 2.2%). The mean number of embryos transferred was similar (2.0 ± 0.0 vs. 1.97 ± 0.3). Concerning embryologic data, there were no statistically significant differences regarding the fertilization, cleavage, top quality day-3 embryo, or blastocyst rates, whereas the top quality blastocyst rate on day 5 was statistically significantly higher in the fresh oocyte group (31.7% vs. 26.1%). Conclusion(s) Aseptically (in a closed system) vitrified oocytes show similar clinical efficiency compared with their sibling fresh oocytes.