Details

Autor(en) / Beteiligte

• Caffo, Maria, M.D., Ph.D
• Caruso, Gerardo, M.D
• Barresi, Valeria, M.D
• Tomasello, Francesco, M.D

Titel

Ossified Intracranial Meningiomas: Description of the First Series of Cases and Review of the Literature

Ist Teil von

• World neurosurgery, 2016-10, Vol.94, p.458-464

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Background Metaplastic meningiomas are characterized by mesenchymal differentiation with formation of bone, cartilage, fat, or xanthomatous elements. However the presence of extensive areas of ossification is rare in meningiomas. In addition, intracranial location of ossified meningiomas is uncommon. Surgical management represents the optimal treatment for ossified meningiomas, but ossification may interfere with surgery and condition outcome. Methods By reviewing patient records and contacting patients, families, and referring physicians, the following information was gathered: age, sex, tumor location, clinical presentation, pre- and postoperative functional status and surgical data. Each surgical specimen had been formalin fixed, paraffin embedded, and cut into parallel 4-μm thick sections for histological evaluation. Results From our research we identified eight cases. All patients had undergone surgical treatment. Histopathological analysis revealed the presence of disorganized bone spicules with solitary, oval, osteocyte nuclei and lined by osteoblasts, with clear evidence of bone tissue in at least 50% of tumor tissue. Conclusions In this study we report the large series, to our knowledge, of surgically treated intracranial ossified meningiomas. The mechanism of ossification in these meningiomas is still unclear and various hypotheses have been formulated. In these cases the complete removal, or a subtotal debulking, in those characterized cases by tenacious adherences to vascular structures and/or critical areas can represent an optimal treatment.