Details

Autor(en) / Beteiligte

• Cha, J.
• Kim, S. T.
• Nam, D.-H.
• Kong, D-S.
• Kim, H.-J.
• Kim, Y. K.
• Kim, H. Y.
• Park, G. M.
• Jeon, P.
• Kim, K. H.
• Byun, H. S.

Titel

Differentiation of Hemangioblastoma from Metastatic Brain Tumor using Dynamic Contrast-enhanced MR Imaging

Ist Teil von

• Clinical neuroradiology (Munich), 2017-09, Vol.27 (3), p.329-334

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose The aim of this study was to differentiate hemangioblastomas from metastatic brain tumors using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and compare the diagnostic performances with diffusion-weighted imaging (DWI) and dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI). Methods We retrospectively reviewed 7 patients with hemangioblastoma and 15 patients with metastatic adenocarcinoma with magnetic resonance imaging (MRI) including DWI, DSC-MRI, and DCE-MRI. Apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV), and DCE-MRI parameters ( K trans , k ep , v e , and v p ) were compared between the two groups. The diagnostic performance of each parameter was evaluated with receiver operating characteristic (ROC) curve analysis. Results v p , k ep , and rCBV were significantly different between patients with hemangioblastoma and those with metastatic brain tumor ( p  < 0.001, p  = 0.005, and p  = 0.017, respectively). A v p cutoff value of 0.012 and a rCBV cutoff value of 8.0 showed the highest accuracy for differentiating hemangioblastoma from metastasis. The area under the ROC curve for v p and rCBV was 0.99 and 0.89, respectively. A v p  > 0.012 showed 100 % sensitivity, 93.3 % specificity, and 95.5 % accuracy and a rCBV > 8.0 showed 85.7 % sensitivity, 93.3 % specificity, and 90.9 % accuracy for differentiating hemangioblastoma from metastatic brain tumor. Conclusion DCE-MRI was useful for differentiating hemangioblastoma from metastatic brain tumor.