Oncoimmunology, 2015-05, Vol.4 (5), p.e1005504-e1005504
2015
Details
- Autor(en) / Beteiligte
- Titel
- Intratumoral delivery of mRNA: Overcoming obstacles for effective immunotherapy
- Ist Teil von
- Oncoimmunology, 2015-05, Vol.4 (5), p.e1005504-e1005504
- Ort / Verlag
- United States: Taylor & Francis
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The immunosuppressive tumor microenvironment (TME) is a major obstacle in cancer immunotherapy. Therefore, it has gained attention as a target site. mRNA emerged as a versatile drug class for cancer therapy. We reported that intratumoral administration of mRNA encoding the fusokine Fβ 2 supports tumor-specific T-cell immunity. This study provides proof of concept of the use of mRNA to modulate the TME.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2162-4011, 2162-402XeISSN: 2162-402XDOI: 10.1080/2162402X.2015.1005504Titel-ID: cdi_proquest_miscellaneous_1826628663
- Format
- –
- Schlagworte
- a fusokine consisting of IFNβ, fused to the ectodomain of the TGFβ receptor II, Author's View, cancer, CD8, CTLs, cytotoxic T lymphocytes, DCs, dendritic cells, dendritic cell, fusokine, IFNβ, immunotherapy, IMP, investigational medicinal product, intratumoral, MDSCs, myeloid-derived suppressor cells, mRNA, receptor II, T cell, TAAs, tumor-associated antigens, TGFβ, TiDCs, tumor-infiltrating DCs, TME, tumor microenvironment