Details

Autor(en) / Beteiligte

• Venkateswaran, Seshasailam
• Wu, Mei
• Gwynne, Peter J
• Hardman, Ailsa
• Lilienkampf, Annamaria
• Pernagallo, Salvatore
• Blakely, Garry
• Swann, David G
• Gallagher, Maurice P
• Bradley, Mark

Titel

Bacteria repelling poly(methylmethacrylate- co -dimethylacrylamide) coatings for biomedical devices†Electronic supplementary information (ESI) available: Polymer microarray screening, including analysis of bacterial adhesion by fluorescence microscopy and SEM, and chemical composition of bacteria repelling polymers identified in the screen; polymer synthesis and characterisation; preparation of catheter pieces and solvent studies, and details for confocal imaging/analysis. See DOI: 10.1039/c4tb0

Ist Teil von

• Journal of materials chemistry. B, Materials for biology and medicine, 2014-09, Vol.2 (39), p.6723-6729

Ort / Verlag

England

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Nosocomial infections due to bacteria have serious implications on the health and recovery of patients in a variety of medical scenarios. Since bacterial contamination on medical devices contributes to the majority of nosocomical infections, there is a need for redesigning the surfaces of medical devices, such as catheters and tracheal tubes, to resist the binding of bacteria. In this work, polyurethanes and polyacrylates/acrylamides, which resist binding by the major bacterial pathogens underpinning implant-associated infections, were identified using high-throughput polymer microarrays. Subsequently, two 'hit' polymers, (poly(methylmethacrylate- -dimethylacrylamide)) and (poly(methoxyethylmethacrylate- -diethylaminoethylacrylate- -methylmethacrylate)), were used to coat catheters and substantially shown to decrease binding of a variety of bacteria (including isolates from infected endotracheal tubes and heart valves from intensive care unit patients). Catheters coated with polymer showed up to 96% reduction in bacteria binding in comparison to uncoated catheters.