Details

Autor(en) / Beteiligte

• Kang, WonYang
• Park, Won-Ju
• Jang, Keun-Ho
• Kim, Soo-Hyeon
• Gwon, Do-Hyeong
• Lim, Hyeong-Min
• Ahn, Ji-Sung
• Moon, Jai-Dong

Titel

Coronary artery atherosclerosis associated with shift work in chemical plant workers by using coronary CT angiography

Ist Teil von

• Occupational and environmental medicine (London, England), 2016-08, Vol.73 (8), p.501-505

Ort / Verlag

England: BMJ Publishing Group

Erscheinungsjahr

2016

Quelle

BMJ Journals Archiv - DFG Nationallizenzen

Beschreibungen/Notizen

• ObjectivesThe aim of this study was to investigate whether shift work is related to elevated risk of coronary artery disease (CAD) by determining the coronary artery calcium (CAC) score and the presence of coronary artery stenosis by using coronary artery CT angiography (CCTA).MethodsIn this study, 110 male workers participated and underwent a CCTA examination for CAC scoring, which represents coronary artery plaque, and were evaluated for luminal stenosis. All of the participants were working in the same chemical plant, of whom 70 worked day shifts and 40 worked rotating shifts.ResultsIn a multivariate logistic regression analysis, including age, smoking status, alcohol consumption, regular exercise and waist circumference, shift work was associated with a 2.89-fold increase in the odds of developing coronary plaque compared with day work (OR, 2.89; 95% CI 1.07 to 7.82). The association between shift work and coronary plaque was strong after adjustment for age, low-density lipoprotein cholesterol, hypertension and diabetes mellitus (OR, 2.92; 95% CI 1.02 to 8.33). In addition, the number of years of shift work employment was associated with coronary plaque. However, no association was found between shift work and coronary artery stenosis.ConclusionsShift work could induce CAD onset via the atherosclerotic process, and shift work employment duration was associated with an increased risk of atherosclerosis in male workers.