Details

Autor(en) / Beteiligte

• Zang, Hao
• Sun, Jian-Guo
• Dong, Xin
• Li, Ping
• Zhang, Bo

Titel

Preparation of Benzothiophenes and Benzoselenophenes from Arylamines and Alkynes via Radical Cascade Reactions

Ist Teil von

• Advanced synthesis & catalysis, 2016-06, Vol.358 (11), p.1746-1752

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2016

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• An intermolecular radical cascade reaction between readily prepared o‐methylthio‐arylamines or o‐methylselanyl‐arylamines and alkynes for the preparation of valuable benzothiophenes or benzoselenophenes is reported. These transformations occur efficiently with complete regioselectivity and the products are obtained in moderate to good yields. The current protocol is successfully applied to the synthesis of the key intermediates of the drug raloxifene and an AT1 receptor antagonist.