Dalton transactions : an international journal of inorganic chemistry, 2016-01, Vol.45 (21), p.8712-8716
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Tuning the reactivity of Sp1 zinc fingers with platinum complexes
- Ist Teil von
- Dalton transactions : an international journal of inorganic chemistry, 2016-01, Vol.45 (21), p.8712-8716
- Ort / Verlag
- England
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- cis-DDP presents reactivity towards the transcription factor Sp1-F3, as opposed to previous observations for Sp1-F2. Replacing the ammine ligands with the chelating ethylenediamine increases the reactivity giving a unique dinuclear {Pt(en)}2-bis(cysteine)-bridged product, confirmed by study of the binding sequence ACPECP.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1477-9226eISSN: 1477-9234DOI: 10.1039/c6dt01128dTitel-ID: cdi_proquest_miscellaneous_1825453182
- Format
- –
- Schlagworte
- Amino Acid Sequence, Ammines, Binding, Chelating, Coordination Complexes - chemistry, Coordination Complexes - metabolism, Ethylenediamine, Humans, Isomerism, Ligands, Magnetic Resonance Spectroscopy, Mass Spectrometry, Platinum, Platinum - chemistry, Protein Binding, Sp1 Transcription Factor - chemistry, Sp1 Transcription Factor - metabolism, Tuning, Zinc, Zinc Fingers