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Biochimica et biophysica acta, 2014-02, Vol.1844 (2), p.384-388
2014
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Autor(en) / Beteiligte
Titel
Extended secondary structures in proteins
Ist Teil von
  • Biochimica et biophysica acta, 2014-02, Vol.1844 (2), p.384-388
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
2014
Quelle
MEDLINE
Beschreibungen/Notizen
  • Supersecondary structures of proteins have been systematically searched and classified, but not enough attention has been devoted to such large edifices beyond the basic identification of secondary structures. The objective of the present study is to show that the association of secondary structures that share some of their backbone residues is a commonplace in globular proteins, and that such deeper fusion of secondary structures, namely extended secondary structures (ESSs), helps stabilize the original secondary structures and the resulting tertiary structures. For statistical purposes, a set of 163 proteins from the protein databank was randomly selected and a few specific cases are structurally analyzed and characterized in more detail. The results point that about 30% of the residues from each protein, on average, participate in ESS. Alternatively, for the specific cases considered, our results were based on the secondary structures produced after extensive Molecular Dynamics simulation of a protein–aqueous solvent system. Based on the very small width of the time distribution of the root mean squared deviations, between the ESS taken along the simulation and the ESS from the mean structure of the protein, for each ESS, we conclude that the ESSs significantly increase the conformational stability by forming very stable aggregates. The ubiquity and specificity of the ESS suggest that the role they play in the structure of proteins, including the domains formation, deserves to be thoroughly investigated. •The association of secondary structures that share some residues is studied.•The extensive secondary structures stabilize the secondary and tertiary structures.•163 proteins characterize statistically the extensive secondary structures.•Molecular simulations confirm the stability of the extensive secondary structures.•The role of the extensive secondary structures deserves to be investigated.
Sprache
Englisch
Identifikatoren
ISSN: 1570-9639, 0006-3002
eISSN: 1878-1454
DOI: 10.1016/j.bbapap.2013.10.005
Titel-ID: cdi_proquest_miscellaneous_1823946628

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