Details

Autor(en) / Beteiligte

• Hutchinson, Peter J
• Kolias, Angelos G
• Timofeev, Ivan S
• Corteen, Elizabeth A
• Czosnyka, Marek
• Timothy, Jake
• Anderson, Ian
• Bulters, Diederik O
• Belli, Antonio
• Eynon, C. Andrew
• Wadley, John
• Mendelow, A. David
• Mitchell, Patrick M
• Wilson, Mark H
• Critchley, Giles
• Sahuquillo, Juan
• Unterberg, Andreas
• Servadei, Franco
• Teasdale, Graham M
• Pickard, John D
• Menon, David K
• Murray, Gordon D
• Kirkpatrick, Peter J

Titel

Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension

Ist Teil von

• The New England journal of medicine, 2016-09, Vol.375 (12), p.1119-1130

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• In a trial comparing decompressive craniectomy with medical therapy in patients with traumatic brain injury and raised intracranial pressure refractory to medical therapy, decompressive craniectomy resulted in lower mortality and higher rates of vegetative state and severe disability. After traumatic brain injury (TBI), intracranial pressure can be elevated owing to a mass effect from intracranial hematomas, contusions, diffuse brain swelling, or hydrocephalus. 1 Intracranial hypertension can lead to brain ischemia by reducing the cerebral perfusion pressure. 2 Intracranial hypertension after TBI is associated with an increased risk of death in most studies. 3 , 4 The monitoring of intracranial pressure and the administration of interventions to lower intracranial pressure are routinely used in patients with TBI, despite the lack of level 1 evidence. 5 Decompressive craniectomy is a surgical procedure in which a large section of the skull is removed and the underlying . . .