Details

Autor(en) / Beteiligte

• Przybyla, Magdalena
• Stevens, Claire H.
• van der Hoven, Julia
• Harasta, Anne
• Bi, Mian
• Ittner, Arne
• van Hummel, Annika
• Hodges, John R.
• Piguet, Olivier
• Karl, Tim
• Kassiou, Michael
• Housley, Gary D.
• Ke, Yazi D.
• Ittner, Lars M.
• van Eersel, Janet

Titel

Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia

Ist Teil von

• Neuroscience letters, 2016-09, Vol.631, p.24-29

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• •The amygdala is a major site of progressive tau pathology in P301S mutant tau-expressing TAU58/2 mice.•TAU58/2 mice present with early-onset disinhibition-like behavior.•Aged TAU58/2 mice are hyperactive in the open field arena. Frontotemporal dementia (FTD) presents clinically with behavioral changes including disinhibition. Mutations in the tau-encoding MAPT gene identified in familial cases of FTD have been used to generate transgenic mouse models of the human condition. Here, we report behavioral changes in a recently developed P301S mutant tau transgenic mouse, including disinhibition-like behavior in the elevated plus maze and hyperactivity in the open field arena. Furthermore, histological analysis revealed the amygdala as a primary and early site of pathological tau deposition in these mice. Taken together, neuropathological and behavioral changes in P301S tau transgenic mice resemble features of human FTD.