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Metabolic flexibility and oxidative capacity independently associate with insulin sensitivity in individuals with newly diagnosed type 2 diabetes
Ist Teil von
Diabetologia, 2016-10, Vol.59 (10), p.2203-2207
Ort / Verlag
Berlin/Heidelberg: Springer Berlin Heidelberg
Erscheinungsjahr
2016
Quelle
MEDLINE
Beschreibungen/Notizen
Aims/hypothesis
Both inherited and acquired insulin resistance have been associated with abnormal muscle mitochondrial function. At whole-body level, maximal oxygen uptake (
V
.
O
2
max
) and/or metabolic flexibility (as given by ΔRQ) reflect certain features of mitochondrial function. This study tests the hypotheses (1) that
V
.
O
2
max
and ΔRQ correlate tightly with each other and with insulin sensitivity and (2) that glycaemia, lipidaemia or subclinical inflammation would explain such relationships.
Methods
Near-normoglycaemic individuals with type 2 diabetes mellitus (
n
= 136) with a short known disease duration (<12 months) underwent cycling spiroergometry, indirect calorimetry and hyperinsulinaemic–euglycaemic clamp tests.
Results
Both
V
.
O
2
max
(
r
= 0.39,
p
< 0.0001) and ΔRQ (
r
= 0.32,
p
< 0.0001) correlated positively with whole-body insulin sensitivity, even after adjusting for anthropometric variables, glycaemia and glucose-lowering medication, but not after adjusting for NEFA.
V
.
O
2
max
further correlated negatively with circulating high-sensitivity C-reactive protein concentration. However,
V
.
O
2
max
did not relate to ΔRQ, even after adjusting for whole-body insulin sensitivity.
Conclusions/interpretation
Oxidative capacity and metabolic flexibility are independent determinants of insulin sensitivity but are influenced by circulating NEFA in recent-onset type 2 diabetes.
ClinicalTrial.gov registration no: NCT01055093