Details

Autor(en) / Beteiligte

• Apostolopoulou, Maria
• Strassburger, Klaus
• Herder, Christian
• Knebel, Birgit
• Kotzka, Jörg
• Szendroedi, Julia
• Roden, Michael

Titel

Metabolic flexibility and oxidative capacity independently associate with insulin sensitivity in individuals with newly diagnosed type 2 diabetes

Ist Teil von

• Diabetologia, 2016-10, Vol.59 (10), p.2203-2207

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Aims/hypothesis Both inherited and acquired insulin resistance have been associated with abnormal muscle mitochondrial function. At whole-body level, maximal oxygen uptake ( V . O 2 max ) and/or metabolic flexibility (as given by ΔRQ) reflect certain features of mitochondrial function. This study tests the hypotheses (1) that V . O 2 max and ΔRQ correlate tightly with each other and with insulin sensitivity and (2) that glycaemia, lipidaemia or subclinical inflammation would explain such relationships. Methods Near-normoglycaemic individuals with type 2 diabetes mellitus ( n  = 136) with a short known disease duration (<12 months) underwent cycling spiroergometry, indirect calorimetry and hyperinsulinaemic–euglycaemic clamp tests. Results Both V . O 2 max ( r  = 0.39, p  < 0.0001) and ΔRQ ( r  = 0.32, p  < 0.0001) correlated positively with whole-body insulin sensitivity, even after adjusting for anthropometric variables, glycaemia and glucose-lowering medication, but not after adjusting for NEFA. V . O 2 max further correlated negatively with circulating high-sensitivity C-reactive protein concentration. However, V . O 2 max did not relate to ΔRQ, even after adjusting for whole-body insulin sensitivity. Conclusions/interpretation Oxidative capacity and metabolic flexibility are independent determinants of insulin sensitivity but are influenced by circulating NEFA in recent-onset type 2 diabetes. ClinicalTrial.gov registration no: NCT01055093