Details

Autor(en) / Beteiligte

• MACKENZIE, BREANNE
• ANDRADE-SOUSA, ADILSON SANTOS
• OLIVEIRA-JUNIOR, MANOEL CARNEIRO
• ASSUMPÇÃO-NETO, ERASMO
• BRANDÃO-RANGEL, MAYSA ALVES RODRIGUES
• SILVA-RENNO, ADRIANO
• SANTOS-DIAS, ALANA
• CICKO, SANJA
• GRIMM, MELANIE
• MÜLLER, TOBIAS
• OLIVEIRA, ANA PAULA LIGEIRO
• MARTINS, MILTON ARRUDA
• IDZKO, MARCO
• VIEIRA, RODOLFO PAULA

Titel

Dendritic Cells Are Involved in the Effects of Exercise in a Model of Asthma

Ist Teil von

• Medicine and science in sports and exercise, 2016-08, Vol.48 (8), p.1459-1467

Ort / Verlag

United States: American College of Sports Medicine

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• INTRODUCTIONThis study investigated the effects of aerobic exercise (AE) on both the maturation of dendritic cells (DC) and the activation of lymphocytes in a mouse model of chronic allergic airway inflammation. METHODSC57BL/6 mice distributed into control, exercise, ovalbumin (OVA), and OVA + exercise groups were submitted to OVA sensitization and challenge. Treadmill training was performed for 4 wk, and mice were assessed for classical features of chronic allergic airway inflammation as well as dendritic cell activation and T-lymphocyte response. RESULTSAE reduced OVA-induced eosinophilic inflammation as observed in bronchoalveolar lavage fluid (P < 0.001), airway walls (P < 0001), and also reduced collagen deposition (P < 0.001). AE also reduced bronchoalveolar lavage fluid cytokines (interleukin [IL]-4, P < 0.001; IL-5, P < 0.01; IL-6, P < 0.001; IL-13, P < 0.01; and tumor necrosis factor α, P < 0.01). Cells derived from mediastinal lymphnodes of AE animals that were restimulated with OVA produced less IL-4 (P < 0.01), IL-5 (P < 0.01), and IL-13 (P < 0.001). In addition, AE reduced both DC activation, as demonstrated by reduced release of IL-6 (P < 0.001), CXCL1/KC (P < 0.01), IL-12p70 (P < 0.01), and tumor necrosis factor α (P < 0.05) and DC maturation, as demonstrated by lower MCH-II expression (P < 0.001). CONCLUSIONAE attenuated dendritic cell and lymphocyte activation and maturation, which contributed to reduced airway inflammation and remodeling in the OVA model of chronic allergic airway inflammation.