Details

Autor(en) / Beteiligte

• He, Jing
• Zhang, Xia
• Wei, Yunbo
• Sun, Xiaolin
• Chen, Yaping
• Deng, Jun
• Jin, Yuebo
• Gan, Yuzhou
• Hu, Xin
• Jia, Rulin
• Xu, Chuanhui
• Hou, Zhaohua
• Leong, Yew Ann
• Zhu, Lei
• Feng, Jinhong
• An, Yuan
• Jia, Yuan
• Li, Chun
• Liu, Xu
• Ye, Hua
• Ren, Limin
• Li, Ru
• Yao, Haihong
• Li, Yuhui
• Chen, Shi
• Zhang, Xuewu
• Su, Yin
• Guo, Jianping
• Shen, Nan
• Morand, Eric F
• Yu, Di
• Li, Zhanguo

Titel

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

Ist Teil von

• Nature medicine, 2016-09, Vol.22 (9), p.991-993

Ort / Verlag

New York: Nature Publishing Group US

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Low-dose IL-2 treatment alters the abundance of regulatory T cells, IL-17-producing T cells and follicular helper T cells, but not of T helper type 1 and 2 cells, in patients with SLE. Systemic lupus erythematosus (SLE) is a potentially life-threatening autoimmune disease characterized by altered balance of activity between effector and regulatory CD4 + T cells. The homeostasis of CD4 + T cell subsets is regulated by interleukin (IL)-2, and reduced production of IL-2 by T cells is observed in individuals with SLE. Here we report that treatment with low-dose recombinant human IL-2 selectively modulated the abundance of regulatory T (T reg ) cells, follicular helper T (T FH ) cells and IL-17-producing helper T (T H 17) cells, but not T H 1 or T H 2 cells, accompanied by marked reductions of disease activity in patients with SLE.