Details

Autor(en) / Beteiligte

• Cai, Qun
• Li, Deng-Kui
• Zhou, Rong-Rong
• Zhuang, Shi-Yi
• Ma, Jin-Tian
• Wu, Yan-Dong
• Wu, An-Xin

Titel

Acid-Catalyzed Multicomponent Tandem Double Cyclization: A One-pot, Metal-free Route to Synthesize Polyfunctional 4,9-Dihydropyrrolo[2,1‑b]quinazolines

Ist Teil von

• Journal of organic chemistry, 2016-09, Vol.81 (17), p.8104-8111

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An acid-catalyzed multicomponent tandem double cyclization protocol has been developed for the synthesis of polyfunctional 4,9-dihydropyrrolo­[2,1-b]­quinazolines from simple and readily available arylglyoxal monohydrates, 2-aminobenzylamine, and trans-β-nitrostyrenes. This practical and metal-free reaction proceeds through an imine formation/cyclization/Michael addition/Henry cyclization protocol, resulting in the construction of four new bonds and two ring moieties directly in one pot.