Details

Autor(en) / Beteiligte

• Bifulco, Carlo B
• Urba, Walter J

Titel

Unmasking PD-1 Resistance by Next-Generation Sequencing

Ist Teil von

• The New England journal of medicine, 2016-09, Vol.375 (9), p.888-889

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2016

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Monoclonal antibodies that inhibit the programmed death 1 (PD-1)–programmed death ligand 1 (PD-L1) pathway are clinically active against a broad range of tumors; however, even the most susceptible tumors (e.g., melanoma) respond less than half the time because of innate resistance. In this issue of the Journal, Zaretsky et al. 1 describe the use of whole-exome sequencing to identify mechanisms of acquired immune resistance in tumors from patients with melanoma who had a relapse after more than 6 months of tumor response to treatment with pembrolizumab. Tumor regression after PD-1–PD-L1 blockade is presumed to be mediated by the activation of tumor-infiltrating . . .