UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 15 von 38
Datensatz exportieren als...
BibTeX
GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome
Molecular cancer research, 2016-08, Vol.14 (8), p.707-719
West, Diana C
Pan, Deng
Tonsing-Carter, Eva Y
Hernandez, Kyle M
Pierce, Charles F
Styke, Sarah C
Bowie, Kathleen R
Garcia, Tzintzuni I
Kocherginsky, Masha
Conzen, Suzanne D
2016
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
West, Diana C
Pan, Deng
Tonsing-Carter, Eva Y
Hernandez, Kyle M
Pierce, Charles F
Styke, Sarah C
Bowie, Kathleen R
Garcia, Tzintzuni I
Kocherginsky, Masha
Conzen, Suzanne D
Titel
GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome
Ist Teil von
Molecular cancer research, 2016-08, Vol.14 (8), p.707-719
Ort / Verlag
United States
Erscheinungsjahr
2016
Quelle
MEDLINE
Beschreibungen/Notizen
In estrogen receptor (ER)-negative breast cancer, high tumor glucocorticoid receptor (GR) expression has been associated with a relatively poor outcome. In contrast, using a meta-analysis of several genomic datasets, here we find that tumor GR mRNA expression is associated with improved ER(+) relapse-free survival (RFS; independently of progesterone receptor expression). To understand the mechanism by which GR expression is associated with a better ER(+) breast cancer outcome, the global effect of GR-mediated transcriptional activation in ER(+) breast cancer cells was studied. Analysis of GR chromatin immunoprecipitation followed by high-throughput sequencing in ER(+)/GR(+) MCF-7 cells revealed that upon coactivation of GR and ER, GR chromatin association became enriched at proximal promoter regions. Furthermore, following ER activation, increased GR chromatin association was observed at ER, FOXO, and AP1 response elements. In addition, ER associated with GR response elements, suggesting that ER and GR interact in a complex. Coactivation of GR and ER resulted in increased expression (relative to ER activation alone) of transcripts that encode proteins promoting cellular differentiation (e.g., KDM4B, VDR) and inhibiting the Wnt signaling pathway (IGFBP4). Finally, expression of these individual prodifferentiation genes was associated with significantly improved RFS in ER(+) breast cancer patients. Together, these data suggest that the coexpression and subsequent activity of tumor cell GR and ER contribute to the less aggressive natural history of early-stage breast cancer by coordinating the altered expression of genes favoring differentiation. The interaction between ER and GR activity highlights the importance of context-dependent nuclear receptor function in cancer. Mol Cancer Res; 14(8); 707-19. ©2016 AACR.
Sprache
Englisch
Identifikatoren
ISSN: 1541-7786
eISSN: 1557-3125
DOI: 10.1158/1541-7786.MCR-15-0433
Titel-ID: cdi_proquest_miscellaneous_1815700227
Format
–
Schlagworte
Breast Neoplasms - genetics
,
Breast Neoplasms - pathology
,
Cell Differentiation
,
Cell Line, Tumor
,
Female
,
Gene Expression Regulation, Neoplastic
,
Humans
,
Receptors, Estrogen - genetics
,
Receptors, Estrogen - metabolism
,
Receptors, Glucocorticoid - genetics
,
Receptors, Glucocorticoid - metabolism
,
Response Elements
,
Signal Transduction
,
Transcription, Genetic
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX