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Prospective randomized controlled study to assess the value of a hemostatic and sealing agent for preventing seroma after axillary lymphadenectomy
Journal of surgical oncology, 2016-09, Vol.114 (4), p.423-427
Piñero-Madrona, Antonio
Castellanos-Escrig, Gregorio
Abrisqueta-Carrión, Jesús
Canteras-Jordana, Manuel
2016
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Piñero-Madrona, Antonio
Castellanos-Escrig, Gregorio
Abrisqueta-Carrión, Jesús
Canteras-Jordana, Manuel
Titel
Prospective randomized controlled study to assess the value of a hemostatic and sealing agent for preventing seroma after axillary lymphadenectomy
Ist Teil von
Journal of surgical oncology, 2016-09, Vol.114 (4), p.423-427
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2016
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Background and Objectives Postoperative seroma after axillary lymphadenectomy leads to an increased use of resources and an impaired quality of life of patients. This randomized clinical trial was designed to assess the value of a hemostatic and sealing agent for decreasing seroma occurrence after axillary lymphadenectomy. Methods A prospective, randomized, blind study was conducted on 91 axillary lymphadenectomies distributed into a control group (n = 47) and a test group in which a collagen sponge coated with human coagulation factors was used (n = 44). Primary end‐points were number of days before removal of axillary drainage, axillary drainage output, and occurrence of seroma, wound infection, haematoma, or wound dehiscence, within 8 weeks of surgery. Bivariate and multivariate analyses on seroma occurrence were performed. Results Seroma occurred in 29 patients (31.86%). A significant direct relationship (P = 0.002) was only noted between use of the hemostatic and sealing agent and nonoccurrence of seroma. In the multivariate study, the only variable found to be significantly related to seroma occurrence was use of the above agent (P = 0.046; odds ratio: 3.365 [95%CI: 1.024–11.060]). Conclusions Use of a collagen sponge coated with human coagulation factors following axillary lymphadenectomy was associated to a lower incidence of postoperative seroma. J. Surg. Oncol. 2016;114:423–427. © 2016 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0022-4790
eISSN: 1096-9098
DOI: 10.1002/jso.24344
Titel-ID: cdi_proquest_miscellaneous_1815681113
Format
–
Schlagworte
Axilla
,
axillary lymphadenectomy
,
axillary lymphadenectomy complications
,
Drug Combinations
,
Female
,
Fibrinogen - therapeutic use
,
Hemostatics - therapeutic use
,
Humans
,
Logistic Models
,
Lymph Node Excision - adverse effects
,
Male
,
Middle Aged
,
postlymphadenectomy seroma
,
Postoperative Complications - prevention & control
,
Prospective Studies
,
sealing agent
,
Seroma - prevention & control
,
Thrombin - therapeutic use
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