Details

Autor(en) / Beteiligte

• Oosthuizen, Nicholette M
• Olivier, Janine
• Martins, Janine
• Schutte, Clara
• Pillay, Tahir S

Titel

Red-Brown Urine in a Patient with Chronic HIV Infection and Quadriparesis

Ist Teil von

• Clinical chemistry (Baltimore, Md.), 2016-09, Vol.62 (9), p.1181-1184

Ort / Verlag

England: American Association for Clinical Chemistry, Inc

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Tests for cytomegalovirus and syphilis were negative. Since commencing HAART, the CD4 count had risen from 79 to 109 ^ 106/L and the HIV viral load had declined from 105 224 to 235 copies/mL (decrease of 2.65 log). Erythrocytes impart a red color to urine, which turns brown within hours due to oxidation of hemoglobin to methemoglobin, particularly at acidic pH. Because erythrocytes, hemoglobin, and myoglobin all produce a positive result in the reagent strip test for blood, hematuria must be confirmed by microscopic vi10.1373/clinchem.2015.250746 sualization of red blood cells. Urine porphyrins were shown on thin-layer chromatography (TLC) to be mostly uroporphyrin with a trace of heptacarboxylic porphyrin. Because fecal total porphyrins were moderately increased at 374 nmol/g dry weight (reference value ^200 nmol/g) consisting of proto- and coproporphyrin with a trace of uroporphyrin on TLC, a diagnosis of acute intermittent porphyria (AIP) was considered.