Lung cancer (Amsterdam, Netherlands), 2016-09, Vol.99, p.4-10
2016
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- Autor(en) / Beteiligte
- Titel
- Expression of programmed death 1 (PD-1) and its ligand (PD-L1) in thymic epithelial tumors: Impact on treatment efficacy and alteration in expression after chemotherapy
- Ist Teil von
- Lung cancer (Amsterdam, Netherlands), 2016-09, Vol.99, p.4-10
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • PD-L1 was positive in 67% of thymoma (TM) and 41% of thymic carcinoma (TC). • Changes in PD-L1 expression were evaluated in TM/TCs by the antibody (E1L3N). • Chemotherapy induced the expression of PD-L1 and PD-1 in TMs. • Immune check point therapies were warranted in TM/TCs.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0169-5002eISSN: 1872-8332DOI: 10.1016/j.lungcan.2016.05.007Titel-ID: cdi_proquest_miscellaneous_1814657499
- Format
- –
- Schlagworte
- Adult, Aged, Antineoplastic Agents - therapeutic use, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, B7-H1 Antigen - genetics, B7-H1 Antigen - metabolism, Biomarkers, Tumor, Chemotherapy, Combined Modality Therapy, Female, Gene Expression, Hematology, Oncology and Palliative Medicine, Humans, Immunogenicity, Immunohistochemistry, Male, Middle Aged, Neoplasms, Glandular and Epithelial - drug therapy, Neoplasms, Glandular and Epithelial - genetics, Neoplasms, Glandular and Epithelial - metabolism, Neoplasms, Glandular and Epithelial - mortality, PD-1, PD-L1, Prognosis, Programmed Cell Death 1 Receptor - genetics, Programmed Cell Death 1 Receptor - metabolism, Pulmonary/Respiratory, Thymic carcinoma, Thymoma, Thymus Neoplasms - drug therapy, Thymus Neoplasms - genetics, Thymus Neoplasms - metabolism, Thymus Neoplasms - mortality, Treatment Outcome