FEBS letters, 2016-08, Vol.590 (16), p.2690-2699
2016
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- Autor(en) / Beteiligte
- Titel
- pVHL‐mediated degradation of HIF‐2α regulates estrogen receptor α expression in normoxic breast cancer cells
- Ist Teil von
- FEBS letters, 2016-08, Vol.590 (16), p.2690-2699
- Ort / Verlag
- England
- Erscheinungsjahr
- 2016
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Estrogen receptor α (ERα) functions as a transcription factor for genes involved in estrogen‐dependent development of breast cancer cells. We demonstrate here that knockdown of hypoxia‐inducible factor (HIF)‐2α, but not of HIF‐1α, increases endogenous ERα protein expression in normoxia and hypoxia. The von Hippel–Lindau protein (pVHL)‐dependent degradation of HIF‐2α participates in the regulation of ERα expression. Additionally, HIF‐2α forms a protein complex with ERα, and amino acids 396–823 of HIF‐2α physically interact with the ligand‐binding domain of ERα. These results indicate that HIF‐2α functions as a negative regulator of ERα expression in breast cancer, especially in normoxia.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1002/1873-3468.12265Titel-ID: cdi_proquest_miscellaneous_1812889358
- Format
- –
- Schlagworte
- Amino Acids - genetics, Amino Acids - metabolism, Basic Helix-Loop-Helix Transcription Factors - genetics, Basic Helix-Loop-Helix Transcription Factors - metabolism, Breast Neoplasms - genetics, Breast Neoplasms - pathology, Cell Hypoxia - genetics, Estrogen Receptor alpha - genetics, Estrogen Receptor alpha - metabolism, estrogen receptor α, Female, Gene Expression Regulation, Neoplastic, Humans, hypoxia‐inducible factor‐2α, Ligands, MCF-7 Cells, Multiprotein Complexes - genetics, Multiprotein Complexes - metabolism, Proteolysis, Von Hippel-Lindau Tumor Suppressor Protein - genetics, Von Hippel-Lindau Tumor Suppressor Protein - metabolism, von Hippel–Lindau protein