Details

Autor(en) / Beteiligte

• Obayashi, Juma
• Tanaka, Kunihide
• Ohyama, Kei
• Manabe, Shutaro
• Nagae, Hideki
• Shima, Hideki
• Sato, Hideaki
• Furuta, Shigeyuki
• Wakisaka, Munechika
• Koike, Junki
• Takagi, Masayuki
• Kitagawa, Hiroaki

Titel

Relation between amount of bile ducts in portal canal and outcomes in biliary atresia

Ist Teil von

• Pediatric surgery international, 2016-09, Vol.32 (9), p.833-838

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Background There is no good prognostic indicator for biliary atresia (BA). We reviewed liver biopsies taken during the initial procedure to find a prognostic marker. Methods Thirty-two BA cases underwent Kasai operation from 1976 to 2009. We compared two groups at 1, 3, and 9 years. Group A required liver transplantation or died. Group B survived with their native liver. Biopsies were analyzed for liver fibrosis, portal-central vein bridging (P–C bridging), ductal plate malformation (DPM) and the number of the bile ducts in portal canal/measured surface area of the portal canal (BDP ratio). Statistical comparisons of the multiple data were evaluated by Mann–Whitney U test, Student’s t test and Pearson’s Chi-square test. Regression analysis with P  < 0.05 was considered significant. Results BDP ratios (/mm 2 ) were 2.4 ± 1.5 in Group A1 ( n  = 9) vs 4.6 ± 2.4 in Group B1 ( n  = 23) ( P  = 0.01); 2.6 ± 1.4 in Group A3 ( n  = 14) vs 5.1 ± 2.5 in Group B3 ( n  = 18) ( P  < 0.01), 3.0 ± 2.2 in Group A9 ( n  = 15) vs 4.9 ± 2.5 in Group B9 ( n  = 15) ( P  < 0.05). There was no significant difference in any other finding. Conclusion The BDP ratio is a sound prognostic indicator in BA.