Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Platinum(iv) anticancer prodrugs - hypotheses and facts
Ist Teil von
Dalton transactions : an international journal of inorganic chemistry, 2016-08, Vol.45 (33), p.12983-12991
Ort / Verlag
England
Erscheinungsjahr
2016
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
In this manuscript we focus on Pt(
iv
) anticancer prodrugs. We explore the main working hypotheses for the design of effective Pt(
iv
) prodrugs and note the exceptions to the common assumptions that are prevalent in the field. Special attention was devoted to the emerging class of "dual action" Pt(
iv
) prodrugs, where bioactive ligands are conjugated to the axial positions of platinum in order to obtain orthogonal or complementary effects that will increase the efficacy of killing the cancer cells. We discuss the rationale behind the design of the "dual action" prodrugs and the results of the pharmacological studies obtained. Simultaneous release of two bioactive moieties inside the cancer cells often triggers several processes that together determine the fate of the cell. Pt(
iv
) complexes provide many opportunities for applying new concepts in targeting, synergistic cell killing and exploiting novel nanodelivery systems.
Do we really know how "dual action" Pt(
iv
) work?