Details

Autor(en) / Beteiligte

• Han, Fengxuan
• Zhu, Caihong
• Guo, Qianping
• Yang, Huilin
• Li, Bin

Titel

Cellular modulation by the elasticity of biomaterials

Ist Teil von

• Journal of materials chemistry. B, Materials for biology and medicine, 2016-01, Vol.4 (1), p.9-26

Ort / Verlag

England

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The behaviors and functions of individual cells, fundamental to the complexity of multicellular organisms, are regulated by their integrated response to a variety of environmental cues such as soluble factors, extracellular matrix (ECM)-mediated signals, and cell-cell interactions. Among these cues, the biomechanical feature of the ECM, represented by its elasticity, has been increasingly recognized as a dominating factor of cell fate. This review article aims to provide an overview of the general principles and recent advances in the field of matrix elasticity-dependent regulation of cellular activities and functions, the underlying biomechanical and molecular mechanisms, as well as pathophysiological implications. A discussion is also provided as to how material design strategies can be used to control the local microenvironment of stem cells to direct their lineage commitment and functions toward tissue development and regeneration. The elasticity of the extracellular matrix has been increasingly recognized as a dominating factor of cell fate and activities. This review provides an overview of the general principles and recent advances in the field of matrix elasticity-dependent regulation of a variety of cellular activities and functions, the underlying biomechanical and molecular mechanisms, as well as the pathophysiological implications.