Details

Autor(en) / Beteiligte

• Nishihama, Yukiko
• Yoshinaga, Jun
• Iida, Ayaka
• Konishi, Shoko
• Imai, Hideki
• Yoneyama, Miyuki
• Nakajima, Daisuke
• Shiraishi, Hiroaki

Titel

Association between paraben exposure and menstrual cycle in female university students in Japan

Ist Teil von

• Reproductive toxicology (Elmsford, N.Y.), 2016-08, Vol.63, p.107-113

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• •Possible effect of paraben exposure on menstrual cycle was explored.•Urinary concentrations of parabens were used as biomarker of exposure.•Shorter menstrual cycle was associated with higher urinary paraben concentrations.•Parabens exposure may be one of environmental determinants of female fecundity. Parabens have been known to have estrogenic activity in many in vivo and in vitro studies and biomonitoring data indicated ubiquitous exposure in general populations. However, there are few human studies on reproductive effects of parabens. In this study, menstrual cycle length and its intra-individual variation were investigated by bleeding record over the period of 5 months and urinary concentrations of parabens were measured for 128 female Japanese university students. We found significantly negative relationships between menstrual cycle length and urinary estrogen-equivalent total paraben (odds=0.73, 95% CI 0.56–0.96) and butyl paraben concentrations (odds=0.83, 0.70–0.99), which indicated shortened cycle length in women with high urinary paraben concentrations. This study indicated that paraben exposure at not excessive levels is associated with menstrual cycle length or its variability among general female subjects. These results suggest a possibility that parabens exposure is one of the environmental causes of human reproductive problem.