Oncogene, 2001-09, Vol.20 (41), p.5810-5817
2001
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- Autor(en) / Beteiligte
- Titel
- WNT pathway and mammary carcinogenesis: Loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type
- Ist Teil von
- Oncogene, 2001-09, Vol.20 (41), p.5810-5817
- Ort / Verlag
- Basingstoke: Nature Publishing
- Erscheinungsjahr
- 2001
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Secreted Frizzled-related protein 1 (SFRP1) encodes a member of a protein family that contains a cysteine-rich domain similar to the WNT-binding site of Frizzled receptors and regulates the WNT pathway. The WNT pathway is frequently altered in human cancers. We have defined the pattern of SFRP1 mRNA expression in the progression of breast cancer. We show that SFRP1 is expressed in the epithelial component of normal breast, in the in situ component of ductal carcinomas and is lost in more than 80% of invasive breast carcinomas except the medullary type. Loss of SFRP1 expression is correlated with the presence of hormonal receptors. Conversely, the maintenance of SFRP1 in carcinomas is correlated with the presence of lymphoplasmocytic stroma. No significant association was observed between SFRP1 status and the level of apoptosis in tumoral cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0950-9232eISSN: 1476-5594DOI: 10.1038/sj.onc.1204706Titel-ID: cdi_proquest_miscellaneous_18117845
- Format
- –
- Schlagworte
- Adult, Aged, Aged, 80 and over, Apoptosis, Apoptosis - physiology, Binding sites, Biological and medical sciences, Breast - metabolism, Breast cancer, Breast carcinoma, Breast Neoplasms - genetics, Breast Neoplasms - metabolism, Breast Neoplasms - pathology, Cancer, Carcinogenesis, Carcinoma in Situ - genetics, Carcinoma in Situ - metabolism, Carcinoma in Situ - pathology, Carcinoma, Ductal, Breast - genetics, Carcinoma, Ductal, Breast - metabolism, Carcinoma, Ductal, Breast - pathology, Carcinoma, Medullary - genetics, Carcinoma, Medullary - metabolism, Carcinoma, Medullary - pathology, Cell physiology, Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes, Chromosomes, Colon, Female, Frizzled protein, Frizzled-related protein, Frizzled-related protein 1, Fundamental and applied biological sciences. Psychology, Gene expression, Gene Silencing, Genes, Glycoproteins - genetics, Glycoproteins - metabolism, Humans, Invasiveness, Middle Aged, Molecular and cellular biology, mRNA, Neoplasm Proteins - genetics, Neoplasm Proteins - metabolism, Proteins, Proto-Oncogene Proteins - metabolism, RNA, Messenger - metabolism, SFRP1 gene, Signal Transduction, Stroma, Tumor suppressor genes, Tumors, Wnt protein, Wnt Proteins, Zebrafish Proteins