Details

Autor(en) / Beteiligte

• Mai, Duy N
• Baxter, Ryan D

Titel

Unprotected Amino Acids as Stable Radical Precursors for Heterocycle C–H Functionalization

Ist Teil von

• Organic letters, 2016-08, Vol.18 (15), p.3738-3741

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An efficient and general method for the C–H alkylation of heteroarenes using unprotected amino acids as stable alkyl radical precursors is reported. This one-pot procedure is performed open to air under aqueous conditions and is effective for several natural and unnatural amino acids. Heterocycles of varying structure are suitably functionalized, and reactivity trends reflect the nucleophilic character of the radical species generated.