Details

Autor(en) / Beteiligte

• Nam, H.-Y.
• Lee, H.Y.
• Park, G.C.

Titel

Impact of co-existent thyroiditis on clinical outcome in papillary thyroid carcinoma with high preoperative serum antithyroglobulin antibody: a retrospective cohort study

Ist Teil von

• Clinical otolaryngology, 2016-08, Vol.41 (4), p.358-364

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Objectives The aim of this study was to investigate the impact of co‐existent chronic lymphocytic thyroiditis (CLT) on changes in serum antithyroglobulin antibody (TgAb) and clinical outcome in papillary thyroid carcinoma (PTC) patients with high preoperative serum TgAb. Design A retrospective cohort study. Setting University teaching hospital. Participants Thirty‐seven PTC patients with high preoperative serum TgAb level (≥100 U/mL) were evaluated. All patients underwent total thyroidectomy followed by high‐dose I‐131 ablation. Main outcome measures Per cent changes of TgAb between pre‐treatment and post‐treatment, and disease‐free survival were calculated. Results Twenty‐two patients (59.5%) had co‐existent CLT, and seven had residual/recurrent tumours. There was a higher proportion of females among the patients with CLT compared to those without CLT (95.5% versus 66.7%; P = 0.0306). There were trends towards more aggressive pathologies, such as tumour size, extrathyroidal extension, surgical margin and lymph node stage, in PTC without CLT than in that with co‐existent CLT. Pre‐treatment and post‐treatment TgAb were all higher in PTC with co‐existent CLT. But, per cent changes of TgAb between pre‐treatment and post‐treatment were no significant difference between PTC with and without CLT (P < 0.05). Patients with co‐existent CLT showed a significantly lower residual/recurrent tumour rate than those without CLT (4.5% versus 40%; P = 0.0113). Conclusion Residual/recurrent tumour rate was lower in PTC patients with co‐existent CLT than in those without CLT.