Details

Autor(en) / Beteiligte

• Stankoff, Bruno
• Jadasz, Janusz Joachim
• Hartung, Hans-Peter
• Küry, Patrick
• Zalc, Bernard
• Lubetzki, Catherine

Titel

Repair strategies for multiple sclerosis: challenges, achievements and perspectives

Ist Teil von

• Current opinion in neurology, 2016-06, Vol.29 (3), p.286-292

Ort / Verlag

England

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Despite major progress in multiple sclerosis (MS) treatment, to date, accumulation of irreversible clinical disability is not sufficiently prevented with immunotherapies. In this context, repair strategies aimed at reducing axonal damage are becoming a very active field of preclinical and clinical research. Improved understanding of the cellular and molecular mechanisms of myelin repair, together with the emergence of new therapeutic candidates are paving the way for novel therapeutic strategies in MS. In parallel, there is a very active development of imaging methods to assess lesions ongoing remyelination that are crucially needed to evaluate therapeutic efficacy. The current development of a very dynamic and multidisciplinary research on remyelination should accelerate the development of myelin repair strategies in MS, to prevent disability progression.