Details

Autor(en) / Beteiligte

• Siritho, Sasitorn
• Sato, Douglas K
• Kaneko, Kimihiko
• Fujihara, Kazuo
• Prayoonwiwat, Naraporn

Titel

The clinical spectrum associated with myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Ab) in Thai patients

Ist Teil von

• Multiple sclerosis, 2016-06, Vol.22 (7), p.964-968

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Background: Myelin oligodendrocyte glycoprotein (anti-MOG) antibody was reported in anti-aquaporin-4 (anti-AQP4) seronegative neuromyelitis optica spectrum disorders (NMOSD) patients. Objectives: To describe clinical phenotypes associated with anti-MOG. Methods: Seventy consecutive Thai patients with inflammatory idiopathic demyelinating central nervous system disorders (IIDCD) who were previously anti-AQP4 seronegative were tested for anti-MOG. Results: Anti-MOG was positive in six patients, representing 20.7% of the IIDCD anti-AQP4 seronegative patients with a non-multiple sclerosis phenotype, and most had relapses. All first presented with optic neuritis with good visual recovery after treatment. Conclusions: Anti-MOG positive patients may have manifestations that mimic NMOSD but differ in their course and prognosis from anti-AQP4 positive NMOSD.