Details

Autor(en) / Beteiligte

• Zhang, Xue
• Ng, Huei Leng Helena, PhD
• Lu, Aiping, PhD
• Lin, Congcong
• Zhou, Limin, PhD
• Lin, Ge, PhD
• Zhang, Yanbo, PhD
• Yang, Zhijun, PhD
• Zhang, Hongqi, PhD

Titel

Drug delivery system targeting advanced hepatocellular carcinoma: Current and future

Ist Teil von

• Nanomedicine, 2016-05, Vol.12 (4), p.853-869

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Abstract Hepatocellular carcinoma (HCC) has a fairly high morbidity and is notoriously difficult to treat due to long latent period before detection, multidrug resistance and severe drug-related adverse effects from chemotherapy. Targeted drug delivery systems (DDS) that can selectively deliver therapeutic drugs into tumor sites have demonstrated a great potential in cancer treatment, which could be utilized to resolve the limitations of conventional chemotherapy. Numerous preclinical studies of DDS have been published, but targeted DDS for HCC has yet to be made for practical clinical use. Since rational targeted DDS design should take cancer-specific properties into consideration, we have reviewed the biological and physicochemical properties of HCC extensively to provide a comprehensive understanding on HCC, and recent DDS studies on HCC, aiming to find some potential targeted DDSs for HCC treatment and a meaningful platform for further development of HCC treatments.