Tumor biology, 2016-05, Vol.37 (5), p.6913-6921
2016
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- Autor(en) / Beteiligte
- Titel
- The MSHA strain of Pseudomonas aeruginosa (PA-MSHA) inhibits gastric carcinoma progression by inducing M1 macrophage polarization
- Ist Teil von
- Tumor biology, 2016-05, Vol.37 (5), p.6913-6921
- Ort / Verlag
- Dordrecht: Springer Netherlands
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Macrophages play crucial roles in promoting tumor development and progression. In the present study, we found that the mannose-sensitive hemagglutination pilus strain of Pseudomonas aeruginosa (PA-MSHA) was efficient in inducing M1 macrophage polarization. PA-MSHA treatment increases expression of M1-related cytokines and promotes activation of murine peritoneal macrophages (MPM). Interestingly, PA-MSHA inhibits cell proliferation and migration and induces the apoptosis of gastric carcinoma cells. These effects of PA-MSHA on M1 polarization were associated with activation of NF-κB expression. Thus, inducing polarization of M1 by PA-MSHA may be one potential strategy for inhibiting gastric carcinoma progression in mice.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1010-4283eISSN: 1423-0380DOI: 10.1007/s13277-015-4451-6Titel-ID: cdi_proquest_miscellaneous_1808653072
- Format
- –
- Schlagworte
- Animals, Apoptosis, Biomedical and Life Sciences, Biomedicine, Cancer Research, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cytokines, Cytokines - biosynthesis, Disease Models, Animal, Disease Progression, Gastric cancer, Heterografts, Macrophage Activation - immunology, Macrophages - immunology, Macrophages - metabolism, Mice, NF-kappa B - metabolism, Nitrites - metabolism, Original Article, Phagocytosis, Pseudomonas aeruginosa, Pseudomonas aeruginosa - physiology, Pseudomonas Infections - microbiology, Signal Transduction, Stomach Neoplasms - etiology, Stomach Neoplasms - pathology, Studies, Superoxides - metabolism, Tumor Burden, Tumor Microenvironment - immunology, Tumors