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Whole‐exome sequencing of duodenal adenocarcinoma identifies recurrent Wnt/β‐catenin signaling pathway mutations
Cancer, 2016-06, Vol.122 (11), p.1689-1696
Yuan, Wei
Zhang, Zhou
Dai, Binghua
Wei, Qing
Liu, Jinjin
Liu, Yuzhen
Liu, Yun
He, Lin
Zhou, Daizhan
2016
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Yuan, Wei
Zhang, Zhou
Dai, Binghua
Wei, Qing
Liu, Jinjin
Liu, Yuzhen
Liu, Yun
He, Lin
Zhou, Daizhan
Titel
Whole‐exome sequencing of duodenal adenocarcinoma identifies recurrent Wnt/β‐catenin signaling pathway mutations
Ist Teil von
Cancer, 2016-06, Vol.122 (11), p.1689-1696
Ort / Verlag
United States
Erscheinungsjahr
2016
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND Genomic alterations of small bowel cancers remain poorly understood due to the rarity of these diseases. In the current study, the authors report the identification of somatic mutations from patients with duodenal adenocarcinoma by whole‐exome sequencing. METHODS Whole‐exome sequencing and follow‐up analysis were conducted in 12 matched tumor‐normal tissue duodenal adenocarcinoma tissue pairs to examine the genetic characteristics of this disease. Somatic mutations (single‐nucleotide variants and short insertion/deletions) were obtained and filtered and then searched for recurrently mutated genes and pathways. RESULTS An excess of C‐to‐T transitions at the CpG dinucleotide was observed in the substitution of bases. The authors identified recurrent mutations in tumor protein p53 (TP53), KRAS, catenin (cadherin‐associated protein) β‐1 (CTNNB1), AT‐rich interactive domain 2 (ARID2), adenomatous polyposis coli (APC), erb‐b2 receptor tyrosine kinase 2 (ERBB2), ARID1A, cadherin‐related family member 1 (CDHR1), NRAS, Bcl‐2‐related ovarian killer (BOK), radial spoke head 14 homolog (chlamydomonas) (RTDR1), cell division cycle 27 (CDC27), catalytic subunit of phosphoinositide‐3‐kinase (PIK3CA), and SMAD family member 4 (SMAD4). Pathway scan indicated that the Wnt signaling pathway, regulation of the actin cytoskeleton pathway, ErbB signaling pathway, and the pathway of focal adhesion were the most extensively affected pathways. CONCLUSIONS This genomic characterization of duodenal adenocarcinoma provides researchers with insight into its somatic landscape and highlights the vital role of the Wnt/β‐catenin signaling pathway. The study data also indicate that duodenal adenocarcinomas have a genetic resemblance to gastric and colorectal cancers. These discoveries may benefit the future development of molecular diagnosis and personalized therapies. Cancer 2016;122:1689‐96. © 2016 American Cancer Society. To the authors' knowledge, there have been very few well‐established genomic characterizations of duodenal adenocarcinoma due its rarity. The identification of base substitutions and recurrently mutated genes and pathways suggest that duodenal adenocarcinoma is genetically akin to gastric and colorectal cancers, and the variation in the Wnt/β‐catenin signaling pathway is a critical event in duodenal tumorigenesis.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.29974
Titel-ID: cdi_proquest_miscellaneous_1808650902
Format
–
Schlagworte
adenocarcinoma
,
Adenocarcinoma - genetics
,
adenomatous polyposis coli (APC)
,
Adult
,
Aged
,
Bcl‐2‐related ovarian killer (BOK)
,
cancer pathways
,
Chlamydomonas
,
DNA Mutational Analysis
,
Duodenal Neoplasms - genetics
,
duodenum
,
Exome
,
Female
,
Gene Deletion
,
high‐throughput nucleotide sequencing
,
Humans
,
Male
,
Middle Aged
,
Mutagenesis, Insertional
,
Mutation
,
Point Mutation
,
Wnt Signaling Pathway - genetics
,
Wnt β‐catenin signaling pathway
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