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Night-time sleep in Parkinson's disease - the potential use of Parkinson's KinetiGraph: a prospective comparative study
Ist Teil von
European journal of neurology, 2016-08, Vol.23 (8), p.1275-1288
Ort / Verlag
England: Blackwell Publishing Ltd
Erscheinungsjahr
2016
Quelle
Access via Wiley Online Library
Beschreibungen/Notizen
Background and purpose
Night‐time sleep disturbances are important non‐motor symptoms and key determinants of health‐related quality of life (HRQoL) in patients with Parkinson's disease (PD). The Parkinson's KinetiGraph (PKG) can be used as an objective measure of different motor states and periods of immobility may reflect episodes of sleep. Our aim was to evaluate whether PKG can be used as an objective marker of disturbed night‐time sleep in PD.
Methods
In this prospective comparative study, data from PKG recordings over six consecutive 24 h periods are compared with Hauser diaries and scales focusing on motor state, sleep and HRQoL in PD patients. Thirty‐three ‘non‐sleepy’ PD patients (PD‐NS) were compared with 30 PD patients presenting with excessive daytime sleepiness (PD‐EDS). The groups were matched for age, gender and Hoehn and Yahr state.
Results
In the PD‐EDS group subjective sleep reports correlated with the PKG's parameters for quantity and quality night‐time sleep, but not in the PD‐NS group. There were no significant correlations of the night‐time sleep quantity parameters of the Hauser diary with subjective sleep perception, neither in the PD‐EDS nor in the PD‐NS group.
Conclusions
This first PKG based study of night‐time sleep in PD suggests that PKG could be used to provide an easy to use and rough evaluation of aspects of night‐time sleep and one that could flag patients where polysomnography may be required. In sleepy PD patients for instance, quantity and quality PKG parameters correlate with different aspects of sleep such as insomnia, parasomnia and restless legs syndrome.