Brain research bulletin, 2016-05, Vol.123, p.53-60
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Transplantation of human retinal pigment epithelial cells in the nucleus accumbens of cocaine self-administering rats provides protection from seeking
- Ist Teil von
- Brain research bulletin, 2016-05, Vol.123, p.53-60
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Some out bred Sprague–Dawley rats take more cocaine than others. • High drug-takers show greater reinstatement of cocaine seeking than Low drug-takers. • RPEC grafts into NAc rescue High drug-takers from reinstatement after 14d abstinence. • RPEC grafts into NAc preserve DA cell bodies in the VTA of High drug-taker rats. • RPEC grafts in NAc protect DA cells in VTA and rescue High takers from reinstatement.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0361-9230eISSN: 1873-2747DOI: 10.1016/j.brainresbull.2015.11.008Titel-ID: cdi_proquest_miscellaneous_1808635828
- Format
- –
- Schlagworte
- Addiction, Animals, Cocaine, Cocaine - pharmacology, Cocaine-Related Disorders - prevention & control, Conditioning, Operant - physiology, Dopamine - pharmacology, Dopaminergic Neurons, Drug-Seeking Behavior - physiology, Epithelial Cells, Extinction, Psychological - physiology, Humans, Male, Neurology, Nucleus Accumbens - metabolism, Prefrontal Cortex - drug effects, Rat, Rats, Rats, Sprague-Dawley, Reinstatement, Retinal Pigment Epithelium - metabolism, Retinal Pigment Epithelium - transplantation, Retinal Pigments, Reward, RPEC, Self Administration, Substance-Related Disorders - prevention & control, Transplant, Ventral Tegmental Area - drug effects