Details

Autor(en) / Beteiligte

• Klinkenberg, Lieke J.J.
• Luyten, Peter
• van der Linden, Noreen
• Urgel, Kim
• Snijders, Daniëlle P.C.
• Knackstedt, Christian
• Dennert, Robert
• Kietselaer, Bastiaan L.J.H.
• Mingels, Alma M.A.
• Cardinaels, Eline P.M.
• Peeters, Frederique E.C.M.
• van Suijlen, Jeroen D.E.
• ten Kate, Joop
• Marsch, Elke
• Theelen, Thomas L.
• Sluimer, Judith C.
• Wouters, Kristiaan
• Bekers, Otto
• Bekkers, Sebastiaan C.A.M.
• van Loon, Luc J.C.
• van Dieijen-Visser, Marja P.
• Meex, Steven J.R.

Titel

Cardiac Troponin T and I Release After a 30-km Run

Ist Teil von

• The American journal of cardiology, 2016-07, Vol.118 (2), p.281-287

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Prolonged endurance-type exercise is associated with elevated cardiac troponin (cTn) levels in asymptomatic recreational athletes. It is unclear whether exercise-induced cTn release mirrors a physiological or pathological underlying process. The aim of this study was to provide a direct comparison of the release kinetics of high-sensitivity cTnI (hs-cTnI) and T (hs-cTnT) after endurance-type exercise. In addition, the effect of remote ischemic preconditioning (RIPC), a cardioprotective strategy that limits ischemia-reperfusion injury, was investigated in a randomized controlled crossover manner. Twenty-five healthy volunteers completed an outdoor 30-km running trial preceded by RIPC (4 × 5 min 220 mm Hg unilateral occlusion) or control intervention. hs-cTnT, hs-cTnI, and sensitive cTnI (s-cTnI) concentrations were examined before, immediately after, 2 and 5 hours after the trial. The completion of a 30-km run resulted in a significant increase in circulating cTn (time: all p <0.001), with maximum hs-cTnT, hs-cTnI, and s-cTnI levels of 47 ± 27, 69 ± 62, and 82 ± 64 ng/L (mean ± SD), respectively. Maximum hs-cTnT concentrations were measured in 60% of the participants at 2 hours after exercise, compared with maximum hs-cTnI and s-cTnI concentrations at 5 hours in 84% and 80% of the participants. Application of an RIPC stimulus did not reduce exercise-induced cTn release (time × trial: all p >0.5). In conclusion, in contrast to acute myocardial infarction, maximum hs-cTnT levels after exercise precede maximum hs-cTnI levels. Distinct release kinetics of hs-cTnT and hs-cTnI and the absence of an effect of RIPC favors the concept that exercise-induced cTn release may be mechanistically distinct from cTn release in acute myocardial infarction.