Brain research bulletin, 2016-05, Vol.123, p.81-93
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Reward devaluation and heroin escalation is associated with differential expression of CRF signaling genes
- Ist Teil von
- Brain research bulletin, 2016-05, Vol.123, p.81-93
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2016
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- Highlights • Heroin SA behavior is associated with differential CRF signaling gene expression. • mRNA expression differences occur in memory, reward and executive brain systems. • Differential mRNA expression of CRH binding protein may be regulated, in part, by CpG methylation. • The NAc is striking in having no changes in mRNA expression in CRF signaling genes. • Alignment of mPFC and Hipp may reflect coordinate CRF signaling in SA behavior.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0361-9230eISSN: 1873-2747DOI: 10.1016/j.brainresbull.2015.11.009Titel-ID: cdi_proquest_miscellaneous_1808629776
- Format
- –
- Schlagworte
- Addiction, Animals, Corticotropin-Releasing Hormone - drug effects, Corticotropin-Releasing Hormone - metabolism, Corticotropin-Releasing Hormone - pharmacology, Cues, DNA methylation, Gene-expression, Heroin, Heroin - metabolism, Heroin - pharmacology, Heroin Dependence - psychology, Hippocampus - drug effects, Hippocampus - metabolism, Male, Neurology, Nucleus Accumbens - drug effects, Nucleus Accumbens - metabolism, Prefrontal Cortex - drug effects, Rats, Reward, Reward devaluation, Saccharin - administration & dosage, Self Administration, Ventral Tegmental Area - drug effects, Ventral Tegmental Area - metabolism