Journal of neuroimmunology, 2016-08, Vol.297, p.38-45
2016
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Impaired regulatory B cells in myasthenia gravis
- Ist Teil von
- Journal of neuroimmunology, 2016-08, Vol.297, p.38-45
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract Regulatory B cells (Bregs) attenuate the severity of experimental autoimmune myasthenia gravis (EAMG) in an interleukin-10 (IL-10)-dependent manner. The goal of this study was to investigate the role of human Bregs in MG focusing on CD19+ CD1dhi CD5+ and CD19+ CD24hi CD38hi subsets. We found that MG patients exhibited a decrease in the frequency of both Breg subsets and IL-10 producing B cells within each subset, which correlated with disease severity. In addition, there was impaired suppression of Th1 polarization in MG. These findings, taken together with EAMG data, indicate that Bregs play an important role in regulating the severity of MG.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0165-5728eISSN: 1872-8421DOI: 10.1016/j.jneuroim.2016.05.004Titel-ID: cdi_proquest_miscellaneous_1808620984
- Format
- –
- Schlagworte
- Adolescent, Adult, Aged, Aged, 80 and over, Allergy and Immunology, B cells, B-Lymphocytes, Regulatory - classification, B-Lymphocytes, Regulatory - immunology, B-Lymphocytes, Regulatory - pathology, Bregs, Cells, Cultured, Cytokines, Cytokines - metabolism, Female, Flow Cytometry, Humans, IL-10, Immune regulation, Male, Middle Aged, Myasthenia Gravis - immunology, Myasthenia Gravis - pathology, Neurology, Neuromuscular junction disorders, Receptors, Cholinergic - metabolism, Young Adult