Details

Autor(en) / Beteiligte

• Todosenko, N.M.
• Shmarov, V.A.
• Malashchenko, V.V.
• Meniailo, M.E.
• Melashchenko, O.B.
• Gazatova, N.D.
• Goncharov, A.G.
• Seledtsov, V.I.

Titel

Erythropoietin exerts direct immunomodulatory effects on the cytokine production by activated human T-lymphocytes

Ist Teil von

• International immunopharmacology, 2016-07, Vol.36, p.277-281

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• The effect of erythropoietin-β (Epo-β) on the functional profile of activated human T-lymphocytes remains largely unknown, which hinders clinical application of Epo as an immunomodulatory agent. We studied the direct impact of Epo on the activation status of human T lymphocytes following activation by particles loaded with antibodies (Abs) against human CD2, CD3, and CD28. T cell activation was assessed by the surface expression of CD38 activation marker. Epo did not significantly affect activation status of both CD4+ and CD4− T cells, as well as of naive (CD45RA+CD197+), central memory (CD45RA−CD197+), effector memory (CD45RA−CD197−), and terminally-differentiated (CD45RA+CD197−) T cells. However, Epo markedly augmented production of IL-2, IL-4 and IL10 by activated T cells with concomitant reduction in IFN-γ secretion. Taken together, our data showed that Epo could directly down-regulate pro-inflammatory T cell responses without affecting T cell activation status. •Еро fails to exert significant effects on T cell activation associated with surface expression of СD38 molecules.•Еро up-regulates Т cell-dependent production of IL-2, IL-4, and IL-10 with concomitant down-regulation of IFN-γ production.•Epo is able to directly down-regulate pro-inflammatory T cell responses without affecting T cell activation status.