Details

Autor(en) / Beteiligte

• Song, Cunfeng
• Yu, Shirong
• Liu, Cheng
• Deng, Yuanming
• Xu, Yiting
• Chen, Xiaoling
• Dai, Lizong

Titel

Preparation of thermo-responsive graft copolymer by using a novel macro-RAFT agent and its application for drug delivery

Ist Teil von

• Materials Science & Engineering C, 2016-05, Vol.62, p.45-52

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• A methodology to prepare thermo-responsive graft copolymer by using a novel macro-RAFT agent was proposed. The macro-RAFT agent with pendant dithioester (ZC(S)SR) was facilely prepared via the combination of RAFT polymerization and esterification reaction. By means of ZC(S)SR-initiated RAFT polymerization, the thermo-responsive graft copolymer consisting of poly(methyl methacrylate-co-hydroxylethyl methacrylate) (P(MMA-co-HEMA)) backbone and hydrophilic poly(N-isopropylacrylamide) (PNIPAAm) side chains was constructed through the “grafting from” approach. The chemical compositions and molecular weight distributions of the synthesized polymers were respectively characterized by 1H nuclear magnetic resonance (1H NMR) and gel permeation chromatography (GPC). Self-assembly behavior of the amphiphilic graft copolymers (P(MMA-co-HEMA)-g-PNIPAAm) was studied by transmission electron microscopy (TEM), dynamic light scattering (DLS) and spectrofluorimeter. The critical micelle concentration (CMC) value was 0.052mgmL−1. These micelles have thermo-responsibility and a low critical solution temperature (LCST) of 33.5°C. Further investigation indicated that the guest molecule release property of these micelles, which can be well described by a first-order kinetic model, was significantly affected by temperature. Besides, the micelles exhibited excellent biocompatibility and cellular uptake property. Hence, these micelles are considered to have potential application in controlled drug delivery. •A novel macro-RAFT agent with ZC(S)SR was used for preparing graft copolymer.•P(MMA-co-HEMA)-g-PNIPAAm was successful prepared via the “grafting from” approach.•Thermo-responsibility of the P(MMA-co-HEMA)-g-PNIPAAm micelles was investigated.•The drug release behavior of the P(MMA-co-HEMA)-g-PNIPAAm micelles was studied.•These micelles exhibited excellent biocompatibility and cellular uptake property.