Details

Autor(en) / Beteiligte

• Lee, Sang-Won
• Markham, Philip F.
• Coppo, Mauricio J. C.
• Legione, Alistair R.
• Markham, John F.
• Noormohammadi, Amir H.
• Browning, Glenn F.
• Ficorilli, Nino
• Hartley, Carol A.
• Devlin, Joanne M.

Titel

Attenuated Vaccines Can Recombine to Form Virulent Field Viruses

Ist Teil von

• Science (American Association for the Advancement of Science), 2012-07, Vol.337 (6091), p.188-188

Ort / Verlag

Washington, DC: American Association for the Advancement of Science

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Recombination between herpesviruses has been seen in vitro and in vivo under experimental conditions. This has raised safety concerns about using attenuated herpesvirus vaccines in human and veterinary medicine and adds to other known concerns associated with their use, including reversion to virulence and disease arising from recurrent reactivation of lifelong chronic infection. We used high-throughput sequencing to investigate relationships between emergent field strains and vaccine strains of infectious laryngotracheitis virus (ILTV, gallid herpesvirus 1). We show that independent recombination events between distinct attenuated vaccine strains resulted in virulent recombinant viruses that became the dominant strains responsible for widespread disease in Australian commercial poultry flocks. These findings highlight the risks of using multiple different attenuated herpesvirus vaccines, or vectors, in the same populations.