Details

Autor(en) / Beteiligte

• Teijaro, John R.
• Ng, Cherie
• Lee, Andrew M.
• Sullivan, Brian M.
• Sheehan, Kathleen C. F.
• Welch, Megan
• Schreiber, Robert D.
• de la Torre, Juan Carlos
• Oldstone, Michael B. A.

Titel

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

Ist Teil von

• Science (American Association for the Advancement of Science), 2013-04, Vol.340 (6129), p.207-211

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2013

Quelle

Science Online_科学在线

Beschreibungen/Notizen

• During persistent viral infections, chronic immune activation, negative immune regulator expression, an elevated interferon signature, and lymphoid tissue destruction correlate with disease progression. We demonstrated that blockade of type I interferon (IFN-I) signaling using an IFN-I receptor neutralizing antibody reduced immune system activation, decreased expression of negative immune regulatory molecules, and restored lymphoid architecture in mice persistently infected with lymphocytic choriomeningitis virus. IFN-I blockade before and after establishment of persistent virus infection resulted in enhanced virus clearance and was CD4 T cell-dependent. Hence, we demonstrate a direct causal link between IFN-I signaling, immune activation, negative immune regulator expression, lymphoid tissue disorganization, and virus persistence. Our results suggest that therapies targeting IFN-I may help control persistent virus infections.