Details

Autor(en) / Beteiligte

• Bernard, Gordon R
• Vincent, Jean-Louis
• Laterre, Pierre-Francois
• LaRosa, Steven P
• Dhainaut, Jean-Francois
• Lopez-Rodriguez, Angel
• Steingrub, Jay S
• Garber, Gary E
• Helterbrand, Jeffrey D
• Ely, E. Wesley
• Fisher, Charles J

Titel

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Ist Teil von

• The New England journal of medicine, 2001-03, Vol.344 (10), p.699-709

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2001

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Severe sepsis, defined as sepsis associated with acute organ dysfunction, results from a generalized inflammatory and procoagulant response to an infection. 1 The rate of death from severe sepsis ranges from 30 to 50 percent despite advances in critical care. 2 – 5 In the United States, approximately 750,000 cases of sepsis occur each year, at least 225,000 of which are fatal. 6 The inflammatory and procoagulant host responses to infection are closely related. 7 Inflammatory cytokines, including tumor necrosis factor α, interleukin-1β, and interleukin-6, are capable of activating coagulation and inhibiting fibrinolysis, whereas the procoagulant thrombin is capable of stimulating multiple inflammatory pathways. 7 – . . .