Details

Autor(en) / Beteiligte

• Tamura, Tomoyoshi
• Hayashida, Kei
• Sano, Motoaki
• Suzuki, Masaru
• Shibusawa, Takayuki
• Yoshizawa, Joe
• Kobayashi, Yosuke
• Suzuki, Takeshi
• Ohta, Shigeo
• Morisaki, Hiroshi
• Fukuda, Keiichi
• Hori, Shingo

Titel

Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome　– First-in-Human Pilot Study

Ist Teil von

• Circulation Journal, 2016/07/25, Vol.80(8), pp.1870-1873

Ort / Verlag

Japan: The Japanese Circulation Society

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background:Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of post-cardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied.Methods and Results:Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome.Conclusions:HI in combination with TTM is a feasible therapy for patients with PCAS. (Circ J 2016; 80: 1870–1873)