Details

Autor(en) / Beteiligte

• González-López, Marcos A., MD, PhD
• Hernández, José L., MD, PhD
• Lacalle, Marina, MD
• Mata, Cristina, MD
• López-Escobar, María, MD
• López-Mejías, Raquel, MD, PhD
• Portilla, Virginia, BSc
• Fuentevilla, Patricia, BSc
• Corrales, Alfonso, MD, PhD
• González-Vela, M. Carmen, MD, PhD
• González-Gay, Miguel A., MD, PhD
• Blanco, Ricardo, MD, PhD

Titel

Increased prevalence of subclinical atherosclerosis in patients with hidradenitis suppurativa (HS)

Ist Teil von

• Journal of the American Academy of Dermatology, 2016-08, Vol.75 (2), p.329-335

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Chronic inflammatory diseases have been associated with increased prevalence of subclinical atherosclerosis. Hidradenitis suppurativa (HS) is a chronic inflammatory disease involving intertriginous skin. Objective We sought to investigate the potential association between HS and subclinical atherosclerosis. Methods This study included 68 patients with HS and 136 age- and sex-matched healthy control subjects. Patients with history of cardiovascular events, diabetes mellitus, chronic kidney disease, or another concomitant inflammatory condition were excluded. Carotid intima-media thickness and carotid plaques were measured by carotid ultrasonography. Adjustments were made for age, sex, and traditional cardiovascular risk factors. Results Patients had greater carotid intima-media thickness values than control subjects (0.615 ± 0.097 vs 0.578 ± 0.098 mm; P  = .012). Carotid plaques were also more frequent in patients than in control subjects (30.9% vs 22.1%). In the multivariable regression model adjusted for age, sex, and traditional cardiovascular risk factors, HS was significantly related to the presence of carotid plaques (odds ratio 2.99, 95% confidence interval 1.26-7.13; P  = .013). Limitations Causality could not be assessed. Conclusions These results indicate an increased frequency of subclinical atherosclerosis in patients with HS. Accordingly, HS should be considered a disease associated with potentially increased cardiovascular risk.