Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (14), p.3879-3884
- Jia, Tianye
- Macare, Christine
- Desrivières, Sylvane
- Gonzalez, Dante A.
- Tao, Chenyang
- Ji, Xiaoxi
- Ruggeri, Barbara
- Nees, Frauke
- Banaschewski, Tobias
- Barker, Gareth J.
- Bokde, Arun L. W.
- Bromberg, Uli
- Büchel, Christian
- Conrod, Patricia J.
- Dove, Rachel
- Frouin, Vincent
- Gallinat, Jürgen
- Garavan, Hugh
- Gowland, Penny A.
- Heinz, Andreas
- Ittermann, Bernd
- Lathrop, Mark
- Lemaitre, Hervé
- Martinot, Jean-Luc
- Paus, Tomáš
- Pausova, Zdenka
- Poline, Jean-Baptiste
- Rietschel, Marcella
- Robbins, Trevor
- Smolka, Michael N.
- Müller, Christian P.
- Feng, Jianfeng
- Rothenfluh, Adrian
- Flor, Herta
- Schumann, Gunter
2016
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Jia, Tianye
- Macare, Christine
- Desrivières, Sylvane
- Gonzalez, Dante A.
- Tao, Chenyang
- Ji, Xiaoxi
- Ruggeri, Barbara
- Nees, Frauke
- Banaschewski, Tobias
- Barker, Gareth J.
- Bokde, Arun L. W.
- Bromberg, Uli
- Büchel, Christian
- Conrod, Patricia J.
- Dove, Rachel
- Frouin, Vincent
- Gallinat, Jürgen
- Garavan, Hugh
- Gowland, Penny A.
- Heinz, Andreas
- Ittermann, Bernd
- Lathrop, Mark
- Lemaitre, Hervé
- Martinot, Jean-Luc
- Paus, Tomáš
- Pausova, Zdenka
- Poline, Jean-Baptiste
- Rietschel, Marcella
- Robbins, Trevor
- Smolka, Michael N.
- Müller, Christian P.
- Feng, Jianfeng
- Rothenfluh, Adrian
- Flor, Herta
- Schumann, Gunter
- Titel
- Neural basis of reward anticipation and its genetic determinants
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (14), p.3879-3884
- Ort / Verlag
- United States: National Academy of Sciences
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila. Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424eISSN: 1091-6490DOI: 10.1073/pnas.1503252113Titel-ID: cdi_proquest_miscellaneous_1805503618
- Format
- –
- Schlagworte
- Addictions, Adolescent, Alcohol Drinking - psychology, Alcohol use, Animals, Anticipation, Psychological - physiology, ATPases Associated with Diverse Cellular Activities, Attention Deficit Disorder with Hyperactivity - genetics, Attention Deficit Disorder with Hyperactivity - physiopathology, Attention Deficit Hyperactivity Disorder, Biological Sciences, Brain, Brain Mapping, Child, Corpus Striatum - physiopathology, Drosophila, Endosomal Sorting Complexes Required for Transport - genetics, Female, Forecasting, Genome-Wide Association Study, Haplotypes - genetics, Humans, Insects, Male, Mental disorders, Motivation, Neuropsychological Tests, Reward, Teenagers, Vacuolar Proton-Translocating ATPases - genetics