Details

Autor(en) / Beteiligte

• Ye, Ke-Yin
• Cheng, Qiang
• Zhuo, Chun-Xiang
• Dai, Li-Xin
• You, Shu-Li

Titel

An Iridium(I) N-Heterocyclic Carbene Complex Catalyzes Asymmetric Intramolecular Allylic Amination Reactions

Ist Teil von

• Angewandte Chemie International Edition, 2016-07, Vol.55 (28), p.8113-8116

Auflage

International ed. in English

Ort / Verlag

Germany: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A chiral iridium(I) N‐heterocyclic carbene complex was reported for the first time as the catalyst in the highly enantioselective intramolecular allylic amination reaction. The current method provides facile access to biologically important enantioenriched indolopiperazinones and piperazinones in good yields (74–91 %) and excellent enantioselectivities (92–99 % ee). Preliminary mechanistic investigations reveal that the C−H activation occurs at the position ortho to the N‐aryl group of the ligand. A chiral iridium(I) N‐heterocyclic carbene complex catalyzes highly enantioselective intramolecular allylic amination reactions. This method provides facile access to biologically important enantioenriched indolopiperazinones and piperazinones in good yields. Mechanistic investigations reveal that the C−H activation occurs at the position ortho to the N‐aryl group of the ligand.